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Brain areas of interest (amygdala, dorsal and ventral hippocampus, PFC) were punched from slices (50m sections) using a cryostat (20C), and cytokine levels analyzed using electrochemiluminescence immunoassay kits
Another study has demonstrated that GIP activation acts synergistically with GLP-1R activation, resulting in greater weight loss in mice than treatment with either agent alone, which correlates with both the enhanced suppression of calorie intake and an increase in energy expenditure (27)
P., & Cleland, S
Tirzepatide produces slightly greater average weight loss (20-22% vs 10-15%), but both medications work through similar mechanisms
Monthly persistency erosion is steeper in obesity: Obesity GLP-1s drop to 32% persistence over 13 months, compared to 41% for diabetes
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